研究方向:

1、热带海洋红树林微生物多样性及药用功能分子发现2、海南特色药用植物次生代谢产物的研究以及药物先导化合物的研发3、靶向信号通路的药理活性机制研究

讲授课程:

主要承担《有机化学》、《有机化学实验》、《天然产物化学》、《化工专业英语》、《有机波谱分析》、《生物化学基础》、《结构分析与表征》等18门博士、硕士、本科生专业课程的教学工作，荣获第三届全国高校青年教师教学竞赛三等奖。

学术兼职:

中国科协海智计划特聘专家，中国海洋学会海洋中药专业委员会副主任委员，中国海洋湖沼学会药学分会理事，中国药学会海洋药物专业委员会委员，“海洋药物博士论坛”青年委员会组委，中国药理学会海洋药物药理专业委员会委员，中国化学会高级会员，中国药学会会员，海南省知识产权局第一批入库专家，海南省生态学会常务理事，海南省女科技工作者协会理事，海南省博士协会副秘书长，海南师范大学化学与化工学院兼职研究员，岭南师范学院红树林研究院第一届学术委员会委员，Mar. Drugs客座编辑，Drug Design Methodologies and Modern Medicinal Chemistry编委，《中国抗生素杂志》编委，《中草药》青年编委，常期担任Mini-Rev. Med. Chem.，LWT-Food Sci. Technol.，Chem. Biodivers.，Curr. Med. Chem.， Fitoterapia， Microb. Biotechnol.，Microb. Pathogenesis，Nat. Prod. Res.，PloS one，Phytochem. Rev.，Phytochem. Lett.，Molecules，《中国海洋药物》等四十余本期刊审稿人。海南大学“热带海洋红树林微生物药物研发创新团队”负责人。

学术成就:

教育部“新世纪优秀人才支持计划”人选，海南省科协青年英才创新计划获得者，海南省科技进步奖三等奖、第四届海南省高等学校优秀研成果二等奖、吴多泰博士科研成果三等奖。

科研项目:

1. 新世纪优秀人才支持计划，NCET-13-0760，特殊生境内生真菌天然产物研究，2014/01-2015/12，已结题，主持。

2. 海南省科协青年科技人才学术创新计划项目，201409，红海榄内生真菌多样性及其化学生态作用，2015/12-2017/12，已结题，主持。

3. 国家自然科学基金面上项目, 81973229, 靶向Wnt/β-catenin通路的红树林共生真菌抗肿瘤活性先导物的发现及机制研究, 2020/1-2023/12,在研，主持。

4. 国家自然科学基金地区基金，82160675，基于CaN/NFAT信号通路的红树林放线菌免疫抑制活性物质的发现与机制研究，2022/1-2025/12，在研，主持。

5.国家自然科学基金地区基金，81660584，红树林烟曲霉菌中新颖免疫抑制活性成分筛选与作用机制研究，2017/01-2020/12，已结题，主持。

6. 国家自然科学基金青年基金，81202456，LC-MS/MS导向红树林内生拟盘多毛孢菌抗肿瘤活性产物快速发现，2013/01-2015/12，已结题，主持。

7. 海南省重点研发计划项目，ZDYF2021SHFZ108，热带海洋红树林内生真菌抗肿瘤活性产物发现及作用机制研究，2021/9-2023/9，在研，主持。

8. 海南省重点研发计划项目，ZDYF2017099，红树林共生真菌资源多样性及活性功能分子筛选，2017/01-2019/12，已结题，主持。

9. 海南省重大科技项目，ZDKJ202018，南海海洋微生物及活性产物的发现和可持续利用，课题二：南海海洋微生物药物先导物资源发现及活性评价, 2020/1-2022/12, 在研, 课题负责人。

10.

11. 广东省海洋药物重点实验室开放课题，LMM2021-4，热带海洋红树林真菌Phomopsis asparagi中免疫抑制剂的发现，2021/12-2023/12，在研, 主持。

12. 海南省自然科学基金高层次人才项目，2019RC006，红树林共生真菌Pestalotiopsis免疫抑制活性物质的筛选与发现，2020/1-2022/12，在研，主持。

13.天津大学-海南大学自主创新基金合作项目，HDTDU201902，红茄苳内生真菌多样性及其农用生物活性代谢产物研究，2019/5-2019/12,已结题，主持。

14.海南省高等学校科学研究重点项目，Hnky2019ZD-6，红树林角果木内生真菌Cytospora sp.药用功能分子的快速发现， 2019/10-2021/12，已结题，主持。

15. 澄迈县生态环境保护局地方政府项目，HD-KYH-2019077,澄迈县富力红树湾水体污染物检测, 2019/04-2020/04,已结题，主持。

16.澄迈县生态环境保护局地方政府项目/HD-KYH-2018136，澄迈县富力红树湾水体污染物检测，2018/04-2019/04，已结题，主持。

17.海南大学协同创新中心2022年度项目，XTCX2022STB01，热带海洋红树林共生真菌沉默基因激活及其—活性次级代谢产物研究，2023/5-2025/8，在研，主持。

17. 海南大学科研团队培育专项资助项目，hdkytg201705，海南红树林植物角果木内生真菌多样性及其生物活性成分研究，2018/01-2020/12，已结题，主持。

18. 国家自然科学基金地区基金项目，31460120，热带雨林土壤种子库小生境特征变化规律及其与种子存活的关系研究，2015/01-2018/12，结题，参加。

19. 海南省自然科学基金，814285，烟曲霉菌中抗氧化活性成分研究，2014/06-2015/06，已结题，主持。

20. 海南省中药现代化专项，ZY201429，大青中抗氧化活性成分研究，2014/01-2015/12，已结题，主持。

21. 海南大学服务地方经济社会发展项目，HDSF201305，热带生物源农药创制关键技术与应用，2014/01-2015/12，已结题，子课题主持。

22. 海南省自然科学基金，211012，红树林植物内共生真菌Pestalotiopsis抗肿瘤活性成分筛选，2011/06-2013/06，已结题，主持。

论著专利:

代表性专著/教材：

1. W. H. Lin^*, G. Q. Li^*, J. Xu.^* Bio-active products from mangrove ecosystems. Mar. Drugs, 2023, ISBN 978-3-0365-7526-1 (Hbk) ISBN 978-3-0365-7527-8 (PDF)

2. 徐静.天然产物化学. 北京：化学工业出版社. ISBN 978-7-122-37960-3.

3. 徐静，梁振益. 天然产物化学实验. 北京：化学工业出版社. ISBN 978-7-122-36029-8.

4. Jing Zhou, Jing Xu^*. Mangrove - Fauna and Flora[M]. InTechOpen Book Chapter: Chemistry and biodiversity of Rhizophora-derived endophytic fungi.

5. 徐静. 红树林微生物天然产物化学研究. 北京：科学出版社. ISBN 978-7-03-041971-2.

6. 周婧, 杨小波, 徐静, 饶晓东. 红茄苳和红海榄内生真菌多样性分析及其生物活性代谢产物研究. 中国农业科学技术出版社. ISBN：9787511654892.

专利研究成果：

1. 徐静, 杨小波, 周婧. 大青中抗氧化活性成分类叶升麻苷的制备. 专利号：ZL201510943019.4.

2. 徐静，周婧，吴希，徐志勇，李钢，岑举人. 一种免疫抑制活性吡喃类新化合物的制备方法和应用. 专利号：ZL201810832424.2.

3. 徐静，一种具有免疫抑制活性的PKS I型聚酮类化合物及其制备方法和应用. 专利号：ZL 201811292869.2.

4. 徐静，岑举人，李钢. 吐叶醇作为有效成分在免疫抑制剂中的应用. 专利号：ZL201910884152.5.

5. 徐静，张雪侠. 一种具有免疫抑制活性的四氢喹啉类生物碱Malaysiensin及其制备方法和应用. 专利号：ZL201910937961.8.

6. 徐静，张雪侠, 冯昭, 韦成文. 一种具有免疫抑制活性的细胞松弛素类化合物及其制备方法和应用. 专利号：ZL2021107400490.0.

7. 徐静，周董董，冯婷，韦成文. 四氢呫吨酮二聚体类化合物在制备抗肿瘤药物中的应用. 专利号：ZL202210386813.3

8. 徐静，邓小林，冯婷，韦成文. 一种具有免疫抑制活性的色酮类化合物及其制备方法和应用. 专利号：ZL202210898333.5

代表性论文：

1. J. J. Ye, R. J. Zou, D. D. Zhou, X. L. Deng, N. L. Wu, D. D. Chen, J. Xu.^* Insights into the phylogenetic diversity, biological activities, and biosynthetic potential of mangrove rhizosphere Actinobacteria from Hainan Island. Front. Microbiol., 2023, 14, 10.3389/fmicb.2023.1157601.

2. J. Xu,^* J. W. Wu, D. D. Zhou, X. X. Zhang, P. F. Leadlay. Efomycine U, a new C₂-asymmetric elaiophylin derivative from Streptomyces malaysiensis DSM 4137. Nat. Prod. Res., 2023, doi.org/10.1080/14786419.2023.2214839.

3. Z. K. Guo, B. T. Chen, D. D. Chen, X. L. Deng, J. Z. Yuan, S. Q. Zhang, Z. J. Xiong, J. Xu.^* New Isocoumarin and Pyrone Derivatives from the Chinese Mangrove Plant Rhizophora mangle-Associated Fungus Phomopsis sp. DHS-11. Molecules, 2023, 28, 3756.

4. W. H. Lin^*, G. Q. Li^*, J. Xu.^* Bio-active products from mangrove ecosystems. Mar. Drugs, 2023, 21, 239.

5. W. F. Zhang, D. Liu, Z. C. Wen, W. H. Lin, J. Xu.^* Chemical investigation of metabolites produced by a deep-sea derived fungus Penicillium sp. Chem. Nat. Compd+, 2023, 59(1), 193-196.

6. 邓小林, 饶乐怡, 徐静,^* Cytochalasin H对小鼠脾细胞增殖的抑制作用及其对Ca²⁺/CaN/NFAT信号通路的影响. 广东海洋大学学报, 2023, 43(4), 网络首发.

7. 周婧, 徐静,^* 红树林内生拟盘多毛孢Pestalotiopsis microspora次级代谢产物及其抗肿瘤活性. 广东海洋大学学报, 2023, 43(4), 网络首发.

8. 吴杰, 陈丹丹, 邓小林, 徐志勇, 徐静,^*海南红树林内生真菌 Endomelanconiopsis endophytica 次级代谢产物及其体外生物活性. 广东海洋大学学报, 2023, 43(4), 网络首发.

9. 周董董, 陈丹丹, 邓小林, 冯婷, 徐静,^* 靶向Wnt/β-catenin信号通路的抗肿瘤活性分子研究进展. 海南师范大学学报（自然科学版）. 2023, 36(2), 223-229.

10. 徐志勇, 熊伟, 吴磊, 刘云飞, 谢传奇, 徐静,^* 红树林植物内生真菌次级代谢产物研究进展(2018—2019年). 中国抗生素杂志, 2023, 48(6), 625-635.

11. W. F. Zhang, Q. Y. Meng, J. S. Wu, W. Cheng, D. Liu, J. Huang, A. L. Fan, J. Xu,^* W. H. Lin. ^* Acorane sesquiterpenes from the deep-sea derived Penicillium bilaiae fungus with anti-neuroinflammatory effects. Front. Chem., 2022, 10.3389/fchem.2022.1036212.

12. F. Ting, C. W. Wei, X. L. Deng, D. D. Chen, Z. C. Wen, J. Xu.^* Epigenetic Manipulation Induced Production of Immunosuppressive Chromones and Cytochalasins from the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48. Mar. Drugs, 2022, 20, 616.

13. Z. Feng, X. X. Zhang, J. W. Wu, C. W. Wei, T. Feng, D. D. Zhou, Z. C. Wen, J. Xu.^* Immunosuppressive cytochalasins from the mangrove endophytic fungus Phomopsis asparagi DHS-48. Mar. Drugs, 2022, 20, 526.

14. J. J. Zhu, G. Li, J. Zhou, Z. Y. Xu, J. Xu.^* Cytoprotective efects and antioxidant activities of acteoside and various extracts of Clerodendrum cyrtophyllum Turcz leaves against t‑BHP induced oxidative damage. Sci. Rep.-UK, 2022, 12, 12630.

15. J. Cai, X. C. Zhu, W. N. Zeng, B. Wang, Y. P. Luo, J. Liu, M. J. Chen, G. Y. Li, G. L. Huang, G. Y. Chen, J. Xu.^* and C. J. Zheng, Talaromarins A–F: Six New Isocoumarins from Mangrove-Derived Fungus Talaromyces flavus TGGP35. Mar. Drugs, 2022, 20, 361.

16. J. Zhou, Z. Feng, W. F. Zhang, J. Xu.^* Evaluation of the Antimicrobial and Cytotoxic Potential of Endophytic Fungi Extracts from Mangrove Plants Rhizophora stylosa and R. mucronate. Sci. Rep.-UK, 2022, 10.1038/s41598-022-06711-9.

17. M. Y. Sun, D. D. Zhou, J. W. Wu, J. Zhou, J. Xu.^*Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. Mar. Drugs, 2022, 20, 125.

18. J. Zhou, D. Y. Zheng, J. Xu.^*Two new polyketides from endophytic fungus Pestalotiopsis sp. HQD-6 isolated from the Chinese mangrove plant Rhizophora mucronata. J. Asian Nat. Prod. Res., 2022, 24(1), 52–58.

19. 徐静,^*邹仁健,陈红军, 温珍昌. 红树林放线菌生物多样性及其抗菌活性代谢产物研究进展. 广东海洋大学学报. 2022, 42(6), 1-10.

20. 陈必婷, 梁振益, 温珍昌, 郭志凯, 徐静.^*红树林来源内生真菌活性产物研究进展. 海南师范大学学报（自然科学版）, 2022, 35(4), 373-385.

21. 张文芳, 李金源, 林文翰, 徐静. ^*Pestalotiopsis属真菌来源ambuic acid 类化学成分及其药理活性研究进展. 国外医药抗生素分册, 2022, 43(5), 322-328.

22. 陈必婷, 吴炜城, 周董董, 邓小林, 张世清, 袁靖喆, 徐静,* 郭志凯.* 两株海南红树植物内生真菌的生物活性成分. 深圳大学学报理工版, 2022, 39(3), 245-252.

23. 周董董, 冯婷, 徐静^*. 红树林内生真菌来源dicerandrol A及其对肝癌HepG2细胞 的增殖抑制作 用及机制的初步研究. 中国抗生素杂志. 2022, 47(5), 471-477.

24. J. Xu.^*, X. X. Zhang, F. L. Huang, G. Li, P. F. Leadlay. Efophylins A and B, two new C2-asymmetric macrodiolide immunosuppressants from Streptomyces malaysiensis DSM 4137. J. Nat. Prod., 2021, 84, 5, 1579–1586.

25. C. W. Wei, C. X. Sun, Z. Feng, X. X. Zhang, J. Xu.^*Four new chromones from the endophytic fungus Phomopsis asparagi DHS-48 isolated from the Chinese mangrove plant Rhizophora mangle. Mar. Drugs, 2021, 19, 348-358.

26. X. X. Zhang, G. Li, Q. Deng, Z. Y. Xu, J. R. Cen, J. Xu.^* Vomifoliol isolated from mangrove plant Ceriops tagal inhibits the NFAT signaling pathway with CN as the target enzyme in vitro. Bioorg. Med. Chem. Lett., 2021, 48, 128235.

27. W. F. Zhang, J. Y. Li, C. W. Wei, X. L. Deng, J. Xu.^* Chemical epigenetic modifiers enhance the production of immunosuppressants from the endophytic fungus Aspergillus fumigatus isolated from Cynodon dactylon. Nat. Prod. Res., 2021, doi.org/10.1080/14786419.2021.1986497.

28. R. J. Zou · C. W. Wei · X. X. Zhang· D. D. Zhou, J. Xu.^*Alkaloids from endophytic fungus Aspergillus fumigatus HQD24 isolated from the Chinese mangrove plant Rhizophora mucronate. Nat. Prod. Res., 2021, doi.org/10.1080/14786419.2021.1916017.

29. W. F. Zhang, Jian-Kun Ma, Xue-Xia Zhang, Yang-Nian Qian and J. Xu.^* Immunosuppressive polyketides from mangrove endophytic fungus Pestalotiopsis sp. HHL-14. Chem. Nat. Compd+, 2021, 57(6), 1130-1133.

30. Zhu, X. C., Chen, S. J., Huang, G. L., Mei, R. Q., Wang, B., Sun, X. P., Nong, X. H., J. Xu.^*, Zheng, C. J. A New Polyketide from the mangrove-derived fungus Phomopsis sp. TJM1-5. Chem. Nat. Compd+, 2021, 57(1), 59-62.

31. X. Zhang, Z. Y. Xu, J. K. Ma, D. D. Zhou, J. Xu.^* Phylogenetic diversity, antimicrobial and antioxidant potential and identification of bioactive compounds from culturable endophytic fungi associated with mangrove Bruguiera sexangula (Lour.) Poir. Curr. Microbiol., 2021, 78, 479–489.

32. X. C. Zhu, G. L. Huang, R. Q. Mei, B. Wang, X. P. Sun, Y. P. Luo, J. Xu.^*, C. J. Zheng*. One new α,β-unsaturated 7-ketone sterol from the mangrove-derived fungus Phomopsis sp.MGF222. Nat. Prod. Res., 2021, 35(21), 3970-3976.

33. 张雪侠, 徐志勇, 邓小林, 徐静. ^* 红树林植物红茄苳内生烟曲霉代谢产物对小鼠脾细胞增殖的影响. 基因组学与应用生物学. 2021,

34. 马建坤，冯昭，邹仁健，彭浩南，徐静^*. 气相色谱-质谱联用（GC-MS）技术解析红树林油状污染物成分及来源. 热带作物学报, 2021, 42(1), 290-296.

35. Z. Y. Xu, X. X. Zhang, J. K. Ma, Y. Yang, J. Zhou, J. Xu.^* Secondary metabolites produced by mangrove endophytic fungus Aspergillus fumigatus HQD24 with immunosuppressive activity. Biochem. Syst. Ecol., 2020, 93, 104166.

36. C. W. Wei, Q. Deng, M. Y. Sun, J. Xu.^* Cytospyrone and cytospomarin: Two new polyketides isolated from mangrove endophytic fungus, Cytospora sp. Molecules, 2020, 25, 4224-4233.

37. G. Li, J. Zhou, M. Y. Sun, J. R. Cen^*, J. Xu.^* Role of luteolin extracted from clerodendrum cyrtophyllum turcz leaves in protecting hepg2 cells from tbhp-induced oxidative stress and its cytotoxicity, genotoxicity. J. Funct. Foods, 2020, 74, 104196.

38. J. Zhou, Q. Yang, X. C. Zhu, T. Lin, D. D. Hao, J. Xu.^*Antioxidant activities of Clerodendrum cyrtophyllum Turcz leaf extracts and their major components. Plos One, 2020, 15(6): e0234435.

39. Z. Y. Xu, X. Wu, G. Li, Z. Feng, J. Xu.^* Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101. Nat. Prod. Res., 2020, 34(7): 1002-1007.

40. X. C. Zhu, R. Q. Mei, B. Wang, C. J. Zheng, J. Xu. Study on bioactive secondary metabolites from a mangrove-derived fungus Phomopsis sp.MGF222, 2020, Chin. J. Mar. Drugs, 2020, 39(4):31-36. (in Chinese).

41. 邓勤, 杨小波, 徐静*.红树植物角果木胚轴化学成分及生物活性研究. 中国抗生素杂志. 2020, 45(10), 982-988.

42. 孙梦宇, 周董董, 邓勤, 徐静^*. 角果木内生真菌活性分子对HeLa细胞增殖凋亡的影响. 热带生物学报, 2020, 11(4), 399-405.

43. J. Xu. Natural products of mangrove-derived microbes. Toxicon, 2019, 158, S28-S29.

44. Z. Y. Xu, B. X. Xiong, J. Xu.^* Chemical investigation of secondary metabolites produced by mangrove endophytic fungus Phyllosticta Capitalensis. Nat. Prod. Res., 2019, doi.org/10.1080/14786419.2019.1656624.

45. J. Zhou, Q.Yang.G.Li. J. Xu.^*Research progress diversity and metabolites of endophytic fungi in mangrove plants. Forest. Science., 2019, 55(1), 89-102. (in Chinese).

46. Z. Feng, X. Zhang, J. Xu.^*Screening active endophytic fungi from Bruguiera sexangula and studying its secondary metabolites. Journal of Huazhong Agricultural University, 2019, 38(6), 1-5. (in Chinese).

47. G. Li, D. H. Li, J. Xu.^*, J. R. Cen*. Evaluation of Antioxidant Activity and Determination of Total Flavonoids and Polyphenols of Clinacanthus nutans. Molecular Plant Breeding, 2019, 17(14) , 4801-4807. (in Chinese).

48. J. Zhou, G. Li, D. Qin, D. Y. Zheng, X. B. Yang, J. Xu.^* Cytotoxic constituents from the mangrove endophytic Pestalotiopsis sp. induce G₀/G₁ cell cycle arrest and apoptosis in human cancer cells. Nat. Prod. Res., 2018, 24(32), 2968-2972.

49. Z. Y. Xu, X. Wu, G. Li, Z. Feng, J. Xu.^*Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101. Nat. Prod. Res., 2018, doi 10.1080/14786419.2018.1539980.

50. J. J. Zhu, J. Xu.^*Protective Effect of Clerodendrum cyrtophyllum Turcz Leaves Extracts on Alcohol-induced Injury in HepG2 Cells. Food Research And Development, 2018, 39(15), 161-167. (in Chinese).

51. Q. Deng, G. Li, M. Y. Sun, X. B. Yang, J. Xu.^*A New Antimicrobial Sesquiterpene Isolated from Endophytic Fungus Cytospora sp. from the Chinese Mangrove Plant Ceriops tagal. Nat. Prod. Res., 2018, doi 10.1080/14786419.2018.1512993.

52. J. Zhou, X. P. Diao, T. Wang, G. Y. Chen, Q. Lin, X. B. Yang, J. Xu.^* Phylogenetic Diversity and Antioxidant Activities of Culturable Fungal Endophytes Associated with the Mangrove Species Rhizophora stylosa and R. mucronata in the South China Sea, Plos One, 2018, 13(6): e0197359.

53. Z. Liu, G. Li, C. Long, J. Xu, J. Cen,* X. Yang. The antioxidant activity and genotoxicity of isogarcinol. Food Chem., 2018, 253, 5-12.

54. Deng Qin, Lü Xiao-bo, J. Xu.^*. Biomolecules produced by endophytic fungi from mangrove Ceriops tagal. Chinese Journal of Antibiotics, 2017, 43(6), 635-644. (in Chinese).

55. Z. Y. Xu, Z. Feng, J. Xu.^* Research advances on antimicrobial activities of microbes derived from mangrove. Chinese Journal of Antibiotics, 2017, 42(4), 241-254. (in Chinese)

56. X. Wu, Q. Deng, Z. Y. Xu, J. R. Cen, J. Xu.^* Application of Preparative High Performance Liquid Chromatography in Separation of Natural Product. Chemical Analysis and Meterage, 2017, 26(1), 113-117. (in Chinese)

57. X. Zhang, J. Li, J. Xu.^*Antioxidant Aactivity of Extracts from Different Parts of the Mangrove Plant Bruguiera sexangula. Chinese Journal of Tropical Crops, 2017, 38(5), 849-853. (in Chinese)

58. J. Zhou, L. Y. Huang, G. Li, J. Xu.^* Isolation, identification and antioxidant activity Aspergillus fumigatus HQD24 endophytic in Rhizophora mucronata. Microbiology China, 2017, 44(8), 1958-1966. (in Chinese)

59. J. Zhou, G. Li, J. Xu.^* Contents analysis antioxident activities of total phenolics and flavonoid from different parts of Rhizophora stylosa. Food Science and Technology, 2017, 42(6), 220-224. (in Chinese)

60. D. H. Xie, J. Xu, Z. M. Li, Z. Y. Liang.* Determination of Total Phenolic Acids and Total Flavonoids in Aerial Roots of Ficus microcarpa L. and Their Antioxidation Activity. Journal of Tropical Biology, 2016, 7(3), 373-375. (in Chinese)

61. D. H. Li, J. Zhou, J. Y. Xia, X. Wu, Y. Y. Huang, X. B. Yang, J. Xu ^*. Antioxidant activities of extract and fractions from Clerodendrum inerme. J. Chem. Pharm. Res., 2015, 7(8), 875-879. (EI cited)

62. J. Xu. Bioactive natural products derived from Mangrove-Associated Microbes. RSC Adv., 2015, 5 (2), 841 – 892.

63. Q. Deng, X. Zhang, F. X. Liu, L. Y. Huang, X. B. Yang, J. Xu.^* Determination of the total phenolic and flavonoid contents in Eupatoriurn odoraturn, as well as their antioxidant activities. J. Chem. Pharm. Res., 2015, 7(1), 986-993. (EI cited)

64. J. Xu, Y. C. Song, Y. Guo, Y. Ning Mei, R. X. Tan. Fumigaclavines D-H, New Ergot Alkaloids from Endophytic Aspergillus fumigatus. Planta Med. 2014, 80, 1131-1137.

65. J. Xu,^* X. B. Yang, Q. Lin^*. Chemistry and biology of Pestalotiopsis-derived natural products. Fungal Divers., 2014, 66, 37-68. (2016-2017 IF= 13.465)

66. J. Xu ^*, X. Q. Luo, W. H. Zhong, J. P. Zhang, R. X. Tan. Characterization of volatile constituents from an endophytic Aspergillus fumigatus strain. J. Chem. Pharm. Res., 2014, 6(4), 893-897. (EI cited)

67. Y. Hemberger,^† J. Xu,^† V. Wray, P. Proksch, J. Wu,G. Bringmann. Pestalotiopens A and B: Stereochemically Challenging Flexible Sesquiterpene-Cyclopaldic Acid Hybrids from Pestalotiopsis sp. Chem. Eur. J. 2013, 19, 15556-15564.

68. J. Zhou , X. X. Zheng, Q. Yang, Z. Y. Liang, D. H. Li, X. B. Yang, J. Xu ^*. Optimization of ultrasonic-assisted extraction and radical-scavenging capacity of phenols and flavonoids from Clerodendrum cyrtophyllum Turcz leaves. PloS one, 2013, 8(7), e68392.

69. D. H. Li, S. H. Yan, P. Proksch, Z. Y. Liang, Q. Lin^*, J. Xu ^*. Volatile metabolites profiling of a Chinese mangrove endophytic Pestalotiopsis sp. strain. Afri. J. Biotechnol. 2013, 12(24), 3802-3806.

70. Z. L. Sun, F. X. Liu, X. Q. Luo, Y. C. Zhang, J. Xu ^*. Volatile constituents of the ligarine extract of Eupatoriurn odoraturn. Adv. Mater. Res., 2013, 726-731, 245-249. (EI cited)

71. X. G. Wang, X. Q. Luo, Y. M. Mei, Q. Lin^*, J. Xu ^*. Comparative evaluation of volatile constituents of the ligarine extracts from different parts of Ficus altissima. Adv. Mater. Res., 2013, 718-720, 275-280. (EI cited)

72. J. Xu, C. B. Cao, D. H. Li, Y. F. Liu, Z. Y. Liang, G. F. Bu, X. B. Yang. Study on the Optimization of Extraction Technology of Flavonoids in Clerodendrum inerme(L.) Gaertn. Roots. Adv. Mater. Res., 2012, 560-561, 349-354. (EI cited)

73. D. H. Li, Z. Y. Liang, M. F. Guo, J. Zhou, X. B. Yang, J. Xu ^*. Study on the chemical composition and extraction technology optimization of essential oil from Wedelia trilobata (L.) Hitchc. Afri. J. Biotechnol. 2012, 11(20), 4513-4517.

74. Q. Lin, Y. F. Liu, Y. K. Chen, Z. Wang, Z. Y. Liang, Y. H. Feng, J. Xu ^*. Comparative evaluation of the chemical composition of essential oil from different parts of Ficus microcarpa. Adv. Mater. Res., 2012, 560-561, 415-422. (EI cited)

75. Q. Lin, H. Y, Du, Y. B. Liu, Y. K. Chen, Y. H. Feng, J. Xu ^*.Comparative evaluation of total flavonoid contents in different parts of Ficus microcarpa. Adv. Mater. Res., 2012, 560-561, 423-427. (EI cited)

76. D. H. Li, Z. Wang, Z. Y. Liang, J. Zhou, G. F. Bu, X. B. Yang, J. Xu ^*. Volatile constituents and antioxidant properties of the ligarine extracts of twig, leaf and root of Clerodendrum inerme. Adv. Mater. Res., 2012, 524-527, 1723-1729. (EI cited)

77. D. H. Li, Z. Wang, Z. Y. Liang, X. B. Yang, J. Xu ^*. Comparative evaluation of the chemical composition of essential oil from twig, leaf and root of Clerodendrum inerme(L.) Gaertn. Adv. Mater. Res., 2012, 343, 22-27. (EI cited)

78. D. L. Zhang, Y. H. Feng, Z. Y. Liang, Q. Lin, J. Xu ^*. Chemical Composition of essential oil from fruit of Ficus altissima. Adv. Mater. Res., 2012, 554-556, 1125-1128. (EI cited)

79. J. Xu^*. Biomolecules Produced by Mangrove-Associated Microbes. Curr. Med. Chem., 2011, 18(34), 5224–5266.

80. J. Xu, A. E. H. A. Hassan, V. Wray, P. Proksch. Polyketide Derivatives of Endophytic Fungus Pestalotiopsis sp. Isolated from the Chinese Mangrove Plant Rhizophora mucronata. Tetra. Lett. 2011, 52(1), 21-25.

81. J. Xu, Q. Lin, B. Wang, V. Wray, W. H. Lin, P. Proksch. Pestalotiopamide E, a new amide from Endophytic Fungus Pestalotiopsis sp. J. Asian Nat. Prod. Res., 2011, 13(4), 373-376.

82. J. Xu^*, Q. Lin, P. Proksch, V. Wray. New Pyrones from the Mangrove Endophytic Fungus Pestalotiopsis sp., 59th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research. Planta Med. 2011, 77, 1334.

83. D. Liu, J. Xu, W. Jiang, Z. W. Deng, N. J. Voogd, P. Proksch, W. H. Lin. Xestospongienols A–L, Brominated Acetylenic Acids from the Chinese Marine Sponge Xestospongia testudinaria. Helv. Chim. Acta, 2011, 94, 1600-1607.

84. J. Xu, S. S. Ebada, P. Proksch. Chemistry and bioactivity of natural products from the fungal genus Pestalotiopsis. Fungal Divers., 2010, 44,15–31.

85. W. M. Hu, J. Xu, J. Sinkkonen, J. Wu. Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues. Mini-Rev Med Chem., 2010, 10(1), 51–61.

86. J. Xu, J. Kjer, J. Sendker, V. Wray, H. S. Guan, R. A. Edrada, W. H. Lin, J. Wu, P. Proksch. Chromones from the Endophytic Fungus Pestalotiopsis sp. Isolated from the Chinese Mangrove Plant Rhizophora mucronata. J. Nat. Prod. 2009, 72(4), 662- 665.

87. J. Xu, J. Kjer, J. Sendker, V. Wray, H. S. Guan, R. A. Edrada, W. E. G. Müller, M. Bayer, W. H. Lin, J. Wu, P. Proksch. Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. Bioor. Med. Chem. 2009, 17(20), 7362–7367.

88. J. Xu, J. Kjer, J. Sendker, V. Wray, H. S. Guan, W. H. Lin, J. Wu, P. Proksch. New polyketides from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. Planta Med. 2009, 75, 1074.

89. X. J. Fu, H. S. Guan, H. B. Liu, J. Xu, D. Z. Jiang, P. J. Qiu. Chemical diversity and correlation analysis of meridian tropism of 129 species of Chinese medicinal herbs. Chinese Journal of Information on TCM, 2009, 16(10), 94-96. (in Chinese)

90. J. Wu, Q. Xiao, J. Xu, et al. Natural products from true mangrove flora: source, chemistry and bioactivities. Nat. Prod. Rep., 2008, 25, 955–981. (2009-2010 IF=7.450)

91. J. Xu, Y. H. Xie, Z. R. Zhang, X. F. Su, W. M. Yuan, Q. Lin. Advance in the research of pharmacological actions of Euphorbiaceae. China Tropical Medicine, 2007, 7(1), 106-107. (in Chinese)

92. J. Xu, Z. Y. Liang, Q. Lin, L. Gao. Study on the Chemical Constituents of Essential Oil from the Baccaurea ramiflora Lour.. Chemical Analysis and Meterage, 2007, 16(3), 42- 43. (in Chinese)

93. J. Xu, Q. Lin, Z. Y. Liang, S. M. Deng, C. X Zhong. Study on the chemical constituents of essential oil from fruit, leaf and root of Baccaurea ramiflora Lour.. Food Science, 2007, 28(11), 439- 442. (in Chinese)

94. J. Xu, Guan Hua-shi, Lin Qiang. A New Sesquiterpene Lactone from Baccaurea ramiflora Lour.. Chinese Herbal Medicine, 2007, 38(10), 1450- 1452. (in Chinese)

95. J. Xu, L. Gao, Y. H. Xie, R. T. Xie, W. M. Yuan, L Hai, Q. Lin. Advance in the pharmacological actions of Sesquiterpene lactone. China Tropical Medicine, 2007, 7(4), 623- 624. (in Chinese)

96. J. Xu, R. T. Xie, Q. Lin, Y. H. Feng, Z. M. Huang, T. X. Chen. The category and bioactivity of polysacchoride of marine organisms. China Tropical Medicine, 2006, 6(7),1277-1278. (in Chinese)

97. X. F. Su, Q. Lin, J. Xu. Hydrolytic Reaction of Organic Compound and its Recent Research. Journal of Nanning Teachers College, 2006, 23(2), 101-104. (in Chinese).

合作交流:

项目组与剑桥大学生物化学系Peter Leadlay教授项目组、德国杜塞尔多夫大学药物与药物生物学研究所Peter Proksch教授项目组、德国布伦瑞克 Helmholtz疾病感染研究中心的Victor Wray博士项目组、中国海洋大学管华诗院士项目组、南京大学谭仁祥教授项目组、北京大学林文翰教授项目组长期保持良好的合作关系，并已经合作开展了一些新颖结构天然产物发现的研究工作。